Diverse immune functions of hemocyanins

CJ Coates, J Nairn - Developmental & Comparative Immunology, 2014 - Elsevier
Substantial evidence gathered recently has revealed the multiple functionalities of
hemocyanin. Contrary to previous claims that this ancient protein is involved solely in …

Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: Current knowledge, challenges, and future opportunities

DA Díaz-Dinamarca, ML Salazar, BN Castillo… - Pharmaceutics, 2022 - mdpi.com
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …

Are the traditional medical uses of Muricidae molluscs substantiated by their pharmacological properties and bioactive compounds?

K Benkendorff, D Rudd, B Devi Nongmaithem, L Liu… - Marine drugs, 2015 - mdpi.com
Marine molluscs from the family Muricidae hold great potential for development as a source
of therapeutically useful compounds. Traditionally known for the production of the ancient …

A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma

S Arancibia, C Espinoza, F Salazar, M Del Campo… - PloS one, 2014 - journals.plos.org
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as
immunomodulatory proteins with proven anti-cancer properties. The biodiversity of …

[HTML][HTML] Hemocyanins stimulate innate immunity by inducing different temporal patterns of proinflammatory cytokine expression in macrophages

TY Zhong, S Arancibia, R Born, R Tampe… - The Journal of …, 2016 - journals.aai.org
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical
outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in …

Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer

JJ Mora Román, M Del Campo, J Villar… - Journal of …, 2019 - Wiley Online Library
Mollusk hemocyanins have been used for decades in immunological and clinical
applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the …

Glycosylation of hemocyanin in Litopenaeus vannamei is an antibacterial response feature

Z Zhang, F Wang, C Chen, Z Zheng, JJ Aweya… - Immunology letters, 2017 - Elsevier
Hemocyanin is an important multifunctional non-specific immune molecule. In this study, we
purified lectin binding and non-lectin binding hemocyanin from Litopenaeus vannamei using …

[HTML][HTML] SNPs of hemocyanin C-terminal fragment in shrimp Litopenaeus vannamei

X Zhao, L Guo, Y Zhang, Y Liu, X Zhang, J Lun, J Chen… - FEBS letters, 2012 - Elsevier
In this study, we identified a variable region in the C-terminus of hemocyanin from the shrimp
Litopenaeus vannamei (2288–2503bp, HcSC) by sequence alignments. A total of 13 SNPs …

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non‐specific immunostimulatory effects

S Arancibia, MD Campo, E Nova… - European journal of …, 2012 - Wiley Online Library
Hemocyanins, which boost the immune system of mammals, have been used as carrier‐
adjuvants to promote Ab production against haptens and peptides, as immunostimulants …

A comprehensive review on hemocyanin from marine products: Structure, functions, its implications for the food industry and beyond

R Ji, L Guan, Z Hu, Y Cheng, M Cai, G Zhao… - International Journal of …, 2024 - Elsevier
Hemocyanin, an oxygen-transport protein, is widely distributed in the hemolymph of marine
arthropods and mollusks, playing an important role in their physiological processes …