Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Ribosomes undergo substantial conformational changes during translation elongation to
accommodate incoming aminoacyl-tRNAs and translocate along the mRNA template. We …

To obtain rates of mRNA synthesis and decay in yeast, we established dynamic
transcriptome analysis (DTA). DTA combines non‐perturbing metabolic RNA labeling with …

Cells coordinate intracellular activities in response to changes in the extracellular
environment to maximize their probability of survival and proliferation. Eukaryotic cells need …

The transcriptome and proteome change dynamically as cells respond to environmental
stress; however, prior proteomic studies reported poor correlation between mRNA and …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

Environmental stresses are usually active during the process of microbial fermentation and
have significant influence on microbial physiology. Microorganisms have developed a series …

Risk assessment methodologies in toxicology have remained largely unchanged for
decades. The default approach uses high dose animal studies, together with human …

Background Gene expression is controlled globally and at multiple levels in response to
environmental stress, but the relationships among these dynamic regulatory changes are …