CRISPR techniques and potential for the detection and discrimination of SARS-CoV-2 variants of concern

H Xiao, J Hu, C Huang, W Feng, Y Liu… - TrAC Trends in …, 2023 - Elsevier
The continuing evolution of the SARS-CoV-2 virus has led to the emergence of many
variants, including variants of concern (VOCs). CRISPR-Cas systems have been used to …

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5

H Shuai, JFW Chan, B Hu, Y Chai, C Yoon, H Liu… - …, 2023 - thelancet.com
Summary Background Among the Omicron sublineages that have emerged, BA. 1, BA. 2,
BA. 5, and their related sublineages have resulted in the largest number of infections. While …

Vaccine effectiveness against hospitalisation estimated using a test-negative case-control study design, and comparative odds of hospital admission and severe …

FCM Kirsebom, K Harman, RJ Lunt… - The Lancet Regional …, 2023 - thelancet.com
Background Since the first emergence of Omicron BA. 1 in England in November 2021,
numerous sub-lineages have evolved. In September 2022, BA. 5 dominated. The …

Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA. 2/5 subvariants in the upper and lower respiratory tract

B Hu, JFW Chan, Y Liu, H Liu, YX Chen, H Shuai… - …, 2024 - thelancet.com
Summary Background Earlier Omicron subvariants including BA. 1, BA. 2, and BA. 5
emerged in waves, with a subvariant replacing the previous one every few months. More …

One pandemic, two solutions: comparing the US-China response and health priorities to COVID-19 from the perspective of “Two Types of Control”

S Lyu, C Qian, A McIntyre, CH Lee - Healthcare, 2023 - mdpi.com
After three years of global rampage, the COVID-19 epidemic, the most serious infectious
disease to occur worldwide since the 1918 influenza pandemic, is nearing its end. From the …

Clinical severity of Omicron subvariants BA. 1, BA. 2, and BA. 5 in a population‐based cohort study in British Columbia, Canada

SL Russell, BRA Klaver, SP Harrigan… - Journal of Medical …, 2023 - Wiley Online Library
Abstract The SARS‐CoV‐2 variant Omicron emerged in late 2021. In British Columbia (BC),
Canada, and globally, three genetically distinct subvariants of Omicron, BA. 1, BA. 2, and …

Comparison of the risk of hospitalisation among BA. 1 and BA. 2 COVID‐19 cases treated with sotrovimab in the community in England

K Harman, SG Nash, HH Webster… - Influenza and Other …, 2023 - Wiley Online Library
There are concerns that sotrovimab has reduced efficacy at reducing hospitalisation risk
against the BA. 2 sub‐lineage of the Omicron SARS‐CoV‐2 variant. We performed a …

In-hospital mortality during the wild-type, alpha, delta, and omicron SARS-CoV-2 waves: a multinational cohort study in the EuCARE project

P Hedberg, M Parczewski, K Serwin… - The Lancet Regional …, 2024 - thelancet.com
Background Investigating outcomes of hospitalised COVID-19 patients throughout the
pandemic is crucial to understand the impact of different SARS-CoV-2 variants. We …

[HTML][HTML] Prevalence and risk factors for long COVID in China: a systematic review and meta-analysis of observational studies

LY Hu, AQ Cai, B Li, YQ Sun, Z Li, JP Liu… - Journal of Infection and …, 2025 - Elsevier
Background With the outbreak of COVID-19 in China, a large number of COVID-19 patients
are at risk of long COVID after recovery. The purpose of our research is to systematically …

COVID-19-related age profiles for SARS-CoV-2 variants in England and Wales and States of the USA (2020 to 2022): Impact on all-cause mortality

RP Jones, A Ponomarenko - Infectious Disease Reports, 2023 - mdpi.com
Since 2020, COVID-19 has caused serious mortality around the world. Given the ambiguity
in establishing COVID-19 as the direct cause of death, we first investigate the effects of age …