The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

In most tissues, the precise control of cell migration and cell-cell interaction is of paramount
importance to the development of a functional structure. Several families of secreted …

Background: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …

Slits are large multidomain leucine-rich repeat (LRR)-containing proteins that provide crucial
guidance cues in neuronal and vascular development. More recently, Slits have been …

Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to
provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion …

Dominant mutations in the T-box transcription factor gene TBX5 cause Holt–Oram syndrome
(HOS), an inherited human disease characterized by upper limb malformations and …

The Slit family of guidance cues binds to Roundabout (Robo) receptors and modulates cell
migration. We report here that ectopic expression of Slit2 and Robo1 or recombinant Slit2 …

The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Several families of evolutionarily conserved axon guidance cues orchestrate the precise
wiring of the nervous system during embryonic development. The remarkable plasticity of …

Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the
Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce …