Recent advancements in snake antivenom production

AS Rathore, R Kumar, OS Tiwari - International journal of biological …, 2023 - Elsevier
Snakebite envenoming (SBE), a neglected tropical disease, claims lives of about 138,000
people globally, and antivenom is the only approved treatment worldwide. However, this …

Revolutionizing snakebite care with novel antivenoms: Breakthroughs and barriers

SO Uko, I Malami, KG Ibrahim, N Lawal, MB Bello… - Heliyon, 2024 - cell.com
Snakebite envenoming (SBE) is a global public health concern, primarily due to the lack of
effective antivenom for treating snakebites inflicted by medically significant venomous …

Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations

A Lafnoune, A Chbel, B Darkaoui, I Nait Irahal… - International Journal of …, 2024 - Springer
Abstract Purpose of Review Snakebite envenomation, classified as a neglected tropical
disease, represents a significant global health threat, particularly in Asia and Africa, where it …

Standard Quality Characteristics and Efficacy of a New Third-Generation Antivenom Developed in Colombia Covering Micrurus spp. Venoms

S Tabares Vélez, LM Preciado, LJ Vargas Muñoz… - Toxins, 2024 - mdpi.com
In Colombia, Micrurus snakebites are classified as severe according to the national clinical
care guidelines and must be treated with specific antivenoms. Unfortunately, these types of …

Selective immunoglobulin aggregates removal in antivenoms by a simple chromatographic step based on a monolithic stationary phase

NB Blanch, O Cascone, M Fingermann - Journal of Chromatography B, 2024 - Elsevier
Antivenom therapy is a critical intervention for treating the more than 5.000. 000
envenomation accidents that occur each year around the world. These immunotherapeutic …

Production of hyperimmune sera: a study of digestion and fractionation methodologies for the purification process of heterologous immunoglobulins

CBP da Costa, VR Carvalho, LLC Ferreira… - Toxin reviews, 2023 - Taylor & Francis
Several scientific studies to evaluate the process of digestion and fractionation of
immunoglobulins have been carried out in order to improve the production of hyperimmune …

[HTML][HTML] Effects of Adjuvant and Immunization Route on Antibody Responses against Naja Naja oxiana Venom

K Sh, S Khamehchian, M Dabaghian… - Archives of Razi …, 2023 - ncbi.nlm.nih.gov
Naja naja oxiana (NNO) is one of the important venomous species in Iran. The current
snakebite treatment is antivenom therapy that deals with hyper immunization of horses with …

[HTML][HTML] 21st century Latin American synthetic peptides for their application in antivenom production

JA Rodríguez, GR Barredo-Vacchelli… - Exploration of Drug …, 2024 - explorationpub.com
Envenomation caused by snakes, scorpions, and spiders represents a serious public health
problem in Latin America. The antivenoms used for its treatment are produced by …

Desenvolvimento e avaliação de antídotos para envenenamento pela serpente Bothrops brazili: investigação do potencial antiofídico de ácidos fenólicos e obtenção …

SS Ferreira - 2022 - bdtd.ibict.br
O ofidismo causa elevada mortalidade e morbidade em muitas regiões do mundo.
Atualmente, o principal tratamento é a soroterapia que apresenta algumas limitações, tais …

A simple and economic three-step process for producing highly purified Fab'fragments directly from the egg yolk water-soluble fraction

MBG Viacava, CL Leiva, ME Tavarone… - … of Chromatography B, 2022 - Elsevier
Although mammals are still the main source of polyclonal antibodies production, the use of
egg yolk immunoglobulins (IgY) is increasing, and thus improvement of its safety to reduce …