Severe respiratory syncytial virus infection in children: burden, management, and emerging therapies

NI Mazur, MT Caballero, MC Nunes - The Lancet, 2024 - thelancet.com
The global burden of respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI)
in young children is high. The RSV prevention strategies approved in 2023 will be essential …

Recent progress toward the discovery of small molecules as novel anti-respiratory syncytial virus agents

T Felicetti, C Sarnari, R Gaito, O Tabarrini… - Journal of Medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …

[HTML][HTML] Early lessons from the implementation of universal respiratory syncytial virus prophylaxis in infants with long-acting monoclonal antibodies, Galicia, Spain …

F Martinón-Torres, S Mirás-Carballal… - …, 2023 - eurosurveillance.org
A monoclonal antibody for universal respiratory syncytial virus prophylaxis in infants has
recently been licensed. We share our experiences of integrating nirsevimab into the regional …

Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus

GL Lin, SB Drysdale, MD Snape, D O'connor… - Nature …, 2024 - nature.com
Respiratory syncytial virus (RSV) is the leading cause of hospitalisation for respiratory
infection in young children. RSV disease severity is known to be age-dependent and highest …

Host responses to respiratory syncytial virus infection

A Agac, SM Kolbe, M Ludlow, ADME Osterhaus… - Viruses, 2023 - mdpi.com
Respiratory syncytial virus (RSV) infections are a constant public health problem, especially
in infants and older adults. Virtually all children will have been infected with RSV by the age …

Validity of clinical severity scores for respiratory syncytial virus: a systematic review

Z Sheikh, E Potter, Y Li, RA Cohen… - The Journal of …, 2024 - academic.oup.com
Background Respiratory syncytial virus (RSV) is a widespread respiratory pathogen, and
RSV-related acute lower respiratory tract infections are the most common cause of …

Respiratory syncytial virus disease in young children and older adults in Europe: a burden and economic perspective

EAF Simões - The Journal of Infectious Diseases, 2022 - academic.oup.com
Soon after the discovery that respiratory syncytial virus (RSV) was the major cause of
bronchiolitis in infants, in 1956 [1], vaccines were developed to try and prevent both infection …

Single‐cell immune profiling reveals markers of emergency myelopoiesis that distinguish severe from mild respiratory syncytial virus disease in infants

N Zivanovic, D Öner, Y Abraham… - Clinical and …, 2023 - Wiley Online Library
Whereas most infants infected with respiratory syncytial virus (RSV) show no or only mild
symptoms, an estimated 3 million children under five are hospitalized annually due to RSV …

[HTML][HTML] The Epidemiology, Clinical, and Economic Burdens of Respiratory Syncytial Virus Infections Amongst Hospitalized Children Under 5 Years of Age in Jordan …

M Abu-Helalah, SF Al-Shatnawi, M Abu Lubad… - Viruses, 2024 - mdpi.com
Respiratory syncytial virus (RSV) has been recognized as a highly important cause of
morbidity and mortality among children and adults. A cross-sectional study at representative …

Viral load at hospitalization is an independent predictor of severe COVID‐19

H Waller, N Carmona‐Vicente, A James… - … Journal of Clinical …, 2022 - pmc.ncbi.nlm.nih.gov
1. BACKGROUND The coronavirus disease 2019 (COVID‐19) pandemic has put immense
pressure on health care systems worldwide. Common symptoms of COVID‐19 include fever …