Until recently, anion (Cl−) channels have received considerably less attention than cation
channels. One reason for this may be that many Cl− channels perform functions that might …

Metadynamics calculations allow investigating structure, plasticity, and energetics in a
variety of biological processes spanning from molecular docking to protein folding. Recent …

Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and
other monovalent anions across cellular membranes in response to intracellular calcium …

Human bestrophin-1 (hBest1) is a calcium-activated chloride channel from the retinal
pigment epithelium, where mutations are associated with vitelliform macular degeneration …

Best vitelliform macular dystrophy (BVMD, also called Best's disease) is a dominantly
inherited, juvenile-onset form of macular degeneration, which is characterized by abnormal …

In the past, a number of candidates have been proposed to form Ca2+ activated Cl−
currents, but it is only recently that two families of proteins, the bestrophins and the TMEM16 …

Purpose: To report 11 cases of autosomal recessive vitelliform macular dystrophy and to
compare their molecular findings and phenotypic characteristics with those of patients with …

Purpose Mutations in bestrophin 1 (BEST1) are associated with a group of retinal disorders
known as bestrophinopathies in man and canine multifocal retinopathies (cmr) in the dog …

Purpose: To describe the phenotype and genotype of patients with autosomal recessive
bestrophinopathy. Methodology: The phenotype of the subjects was described after a …

Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to
human physiology and a myriad of eye diseases termed “bestrophinopathies”. Since the …