Molecular mechanisms of exercise contributing to tissue regeneration

J Chen, R Zhou, Y Feng, L Cheng - Signal Transduction and Targeted …, 2022 - nature.com
Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

Electrical stimulation to promote peripheral nerve regeneration

MP Willand, MA Nguyen… - … and neural repair, 2016 - journals.sagepub.com
Peripheral nerve injury afflicts individuals from all walks of life. Despite the peripheral
nervous system's intrinsic ability to regenerate, many patients experience incomplete …

Heparin-poloxamer thermosensitive hydrogel loaded with bFGF and NGF enhances peripheral nerve regeneration in diabetic rats

R Li, Y Li, Y Wu, Y Zhao, H Chen, Y Yuan, K Xu… - Biomaterials, 2018 - Elsevier
Peripheral nerve injury (PNI) is a major burden to society with limited therapeutic options,
and novel biomaterials have great potential for shifting the current paradigm of treatment …

The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met

CE McGregor, AW English - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

3D‐printed nerve conduits with live platelets for effective peripheral nerve repair

J Tao, H Liu, W Wu, J Zhang, S Liu… - Advanced Functional …, 2020 - Wiley Online Library
Platelets can secrete multiple growth factors for peripheral nerve repair. However, topically
injected platelets are rapidly activated followed by burst release of the cargos, causing …

Rehabilitation strategies after spinal cord injury: inquiry into the mechanisms of success and failure

MP Côté, M Murray, MA Lemay - Journal of neurotrauma, 2017 - liebertpub.com
Body-weight supported locomotor training (BWST) promotes recovery of load-bearing
stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is …

Advances and future applications of augmented peripheral nerve regeneration

S Jones, HM Eisenberg, X Jia - International journal of molecular sciences, 2016 - mdpi.com
Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and
economic costs. Much research continues to be performed in areas related to improving the …

Ageing and exercise‐induced motor unit remodelling

EJ Jones, SY Chiou, PJ Atherton… - The Journal of …, 2022 - Wiley Online Library
A motor unit (MU) comprises the neuron cell body, its corresponding axon and each of the
muscle fibres it innervates. Many studies highlight age‐related reductions in the number of …

The use of the rat as a model for studying peripheral nerve regeneration and sprouting after complete and partial nerve injuries

T Gordon, GH Borschel - Experimental neurology, 2017 - Elsevier
Rat models of complete and partial injuries are the most frequently used models for analysis
of the cellular and molecular processes of nerve regeneration and axon sprouting. Studies …

Bench‐to‐bedside lessons learned: commercialization of an acellular nerve graft

M Kasper, C Deister, F Beck… - Advanced Healthcare …, 2020 - Wiley Online Library
Peripheral nerve injury can result in debilitating outcomes including loss of function and
neuropathic pain. Although nerve repair research and therapeutic development are widely …