Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

This study investigated the effect of nicotinamide (NAM) supplementation on the
development of brain inflammation and microglial activation in a mouse model of type 1 …

Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in
scientific studies to examine oxidative stress and its impact on biological systems. Trolox has …

The dysfunction of myelinating glial cells, the oligodendrocytes, within the central nervous
system (CNS) can result in the disruption of myelin, the lipid-rich multi-layered membrane …

Neurodegenerative diseases have common underlying pathological mechanisms including
progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial …

Significance: Nicotinamide adenine dinucleotide (NAD+) acts as a cofactor in many
important biological processes. The administration of NAD+ precursors increases the …

Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a
thorough knowledge of their complex molecular mechanisms. A diverse set of cell signaling …