The essential elements of Alzheimer's disease

P Lei, S Ayton, AI Bush - Journal of Biological Chemistry, 2021 - ASBMB
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Oxidative stress: a key modulator in neurodegenerative diseases

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2019 - mdpi.com
Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Magnetic field effects in biology from the perspective of the radical pair mechanism

H Zadeh-Haghighi, C Simon - Journal of the Royal …, 2022 - royalsocietypublishing.org
Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …

The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

[HTML][HTML] The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

[HTML][HTML] Consciousness in the universe: A review of the 'Orch OR'theory

S Hameroff, R Penrose - Physics of life reviews, 2014 - Elsevier
The nature of consciousness, the mechanism by which it occurs in the brain, and its ultimate
place in the universe are unknown. We proposed in the mid 1990's that consciousness …

Metals and neurodegenerative diseases. A systematic review

CE Cicero, G Mostile, R Vasta, V Rapisarda… - Environmental …, 2017 - Elsevier
Neurodegenerative processes encompass a large variety of diseases with different
pathological patterns and clinical presentation such as Amyotrophic Lateral Sclerosis (ALS) …

Role of environmental contaminants in the etiology of Alzheimer's disease: a review

M Yegambaram, B Manivannan… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70%
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …

Nutrition and the Risk of Alzheimer′ s Disease

N Hu, JT Yu, L Tan, YL Wang, L Sun… - BioMed research …, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is a progressive neurodegenerative disorder that accounts for
the major cause of dementia, and the increasing worldwide prevalence of AD is a major …