Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl- ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …
MK Sen, DA Mahns, JR Coorssen… - … & Biobehavioral Reviews, 2019 - Elsevier
The feeding of cuprizone (CPZ) to animals has been extensively used to model the processes of demyelination and remyelination, with many papers adopting a narrative linked …
NADPH oxidase (NOX)‐dependent reactive oxygen species (ROS) production in inflammatory cells including microglia plays an important role in demyelination and free …
JY Broos, RTM van der Burgt, J Konings… - Journal of …, 2024 - Springer
Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration …
K Iwasa, S Yamamoto, K Yamashina… - Journal of …, 2021 - Springer
Background Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory …
S Yamamoto, K Yamashina, M Ishikawa… - Journal of …, 2017 - Springer
Background Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and …
KF Paton, S Hong, A Biggerstaff, BM Kivell - Brain Sciences, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test …
M Hashimoto, S Yamamoto, K Iwasa, K Yamashina… - Brain research …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles …
NA Sharif, PG Klimko - British journal of pharmacology, 2019 - Wiley Online Library
In contrast to the availability of potent and selective antagonists of several prostaglandin receptor types (including DP1, DP2, EP and TP receptors), there has been a paucity of well …