Motor behavioral deficits in the cuprizone model: Validity of the rotarod test paradigm

C Lubrich, P Giesler, M Kipp - International journal of molecular sciences, 2022 - mdpi.com
Multiple Sclerosis (MS) is a neuroinflammatory disorder, which is histopathologically
characterized by multifocal inflammatory demyelinating lesions affecting both the central …

[HTML][HTML] Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families

M Simard, AS Archambault, JPC Lavoie… - Biochemical …, 2022 - Elsevier
Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …

Behavioural phenotypes in the cuprizone model of central nervous system demyelination

MK Sen, DA Mahns, JR Coorssen… - … & Biobehavioral Reviews, 2019 - Elsevier
The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Microglial Hv1 proton channel promotes cuprizone‐induced demyelination through oxidative damage

J Liu, D Tian, M Murugan, UB Eyo… - Journal of …, 2015 - Wiley Online Library
NADPH oxidase (NOX)‐dependent reactive oxygen species (ROS) production in
inflammatory cells including microglia plays an important role in demyelination and free …

Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?

JY Broos, RTM van der Burgt, J Konings… - Journal of …, 2024 - Springer
Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous
system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration …

A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse …

K Iwasa, S Yamamoto, K Yamashina… - Journal of …, 2021 - Springer
Background Neuroinflammation is a key pathological component of neurodegenerative
disease and is characterized by microglial activation and the secretion of proinflammatory …

Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

S Yamamoto, K Yamashina, M Ishikawa… - Journal of …, 2017 - Springer
Background Multiple sclerosis is a neuroinflammatory demyelinating and
neurodegenerative disease of the central nervous system characterized by recurrent and …

Sex differences in the behavioural aspects of the cuprizone-induced demyelination model in mice

KF Paton, S Hong, A Biggerstaff, BM Kivell - Brain Sciences, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central
nervous system. The cuprizone-induced demyelination model is often used in mice to test …

The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation

M Hashimoto, S Yamamoto, K Iwasa, K Yamashina… - Brain research …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system
characterized by recurrent and progressive demyelination/remyelination cycles …

Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility

NA Sharif, PG Klimko - British journal of pharmacology, 2019 - Wiley Online Library
In contrast to the availability of potent and selective antagonists of several prostaglandin
receptor types (including DP1, DP2, EP and TP receptors), there has been a paucity of well …