Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
New routes in GPCR/β-arrestin-driven signaling in cancer progression and metastasis
Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization
and activation of signaling pathways, which in turn determine changes in actin cytoskeleton …
and activation of signaling pathways, which in turn determine changes in actin cytoskeleton …
Smoking-mediated upregulation of the androgen pathway leads to increased SARS-CoV-2 susceptibility
J Chakladar, N Shende, WT Li, M Rajasekaran… - International journal of …, 2020 - mdpi.com
The COVID-19 pandemic is marked by a wide range of clinical disease courses, ranging
from asymptomatic to deadly. There have been many studies seeking to explore the …
from asymptomatic to deadly. There have been many studies seeking to explore the …
Inhibition of BMI1 induces autophagy-mediated necroptosis
The clonal self-renewal property conferred by BMI1 is instrumental in maintenance of not
only normal stem cells but also cancer-initiating cells from several different malignancies …
only normal stem cells but also cancer-initiating cells from several different malignancies …
β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
P Tocci, R Cianfrocca, V Di Castro, L Rosanò… - Nature …, 2019 - nature.com
The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with
high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic …
high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic …
β-Arrestins: multitask scaffolds orchestrating the where and when in cell signalling
SA Laporte, MGH Scott - Beta-Arrestins: Methods and Protocols, 2019 - Springer
The β-arrestins (β-arrs) were initially appreciated for the roles they play in the
desensitization and endocytosis of G protein-coupled receptors (GPCRs). They are now also …
desensitization and endocytosis of G protein-coupled receptors (GPCRs). They are now also …
β-arrestin1 at the cross-road of endothelin-1 signaling in cancer
The advent of targeted therapeutics in human cancer has begun to find novel druggable
targets and, in this context, the endothelin-1 receptor (ET-1R), namely ET A receptor (ET AR) …
targets and, in this context, the endothelin-1 receptor (ET-1R), namely ET A receptor (ET AR) …
Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling
C Walther, SSG Ferguson - Molecular Endocrinology, 2015 - academic.oup.com
The majority of hormones stimulates and mediates their signal transduction via G protein-
coupled receptors (GPCRs). The signal is transmitted into the cell due to the association of …
coupled receptors (GPCRs). The signal is transmitted into the cell due to the association of …
Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis
Y Ye, H Jiang, Y Wu, G Wang, Y Huang… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: β-arrestin1 (ARRB1), was originally identified as a multifunctional adaptor
protein. Although ARRB1 has recently been shown to also play an important role in tumor …
protein. Although ARRB1 has recently been shown to also play an important role in tumor …
ARRB2 promotes colorectal cancer growth through triggering WTAP
H Liang, Z Lin, Y Ye, R Luo… - Acta biochimica et …, 2021 - academic.oup.com
Colorectal cancer (CRC) is one of the most lethal cancers worldwide. The expression of β-
arrestin2 (β-Arr2, ARRB2) in CRC has been well investigated; however, its exact mechanism …
arrestin2 (β-Arr2, ARRB2) in CRC has been well investigated; however, its exact mechanism …