Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease

E Peprah, H Xu, F Tekola-Ayele, CD Royal - Public Health Genomics, 2015 - karger.com
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …

[HTML][HTML] Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities

WJAJ Hendriks, R Pulido - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism to steer
normal development and physiological functioning of multicellular organisms …

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

N Siddiqui, AJ Zwetsloot, A Bachmann, D Roth… - Nature …, 2019 - nature.com
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core
vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the …

The genomic psychiatry cohort: partners in discovery

MT Pato, JL Sobell, H Medeiros… - American Journal of …, 2013 - Wiley Online Library
Abstract The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to
provide the necessary population‐based sample for large‐scale genomic studies, studies …

[HTML][HTML] Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing

X Yang, Y Mao, XK Wang, DN Ma, Z Xu… - Zoological …, 2023 - ncbi.nlm.nih.gov
The common marmoset (Callithrix jacchus) has emerged as a valuable nonhuman primate
model in biomedical research with the recent release of high-quality reference genome …

Selection signatures of Fuzhong Buffalo based on whole-genome sequences

T Sun, G Huang, Z Wang, S Teng, Y Cao, J Sun… - BMC genomics, 2020 - Springer
Background Fuzhong buffalo, a native breed of Guangxi Zhuang Autonomous Region, is
traditionally used as a draft animal to provide farm power in the rice cultivation. In addition …

De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies

SN Manivannan, J Roovers, N Smal, CT Myers… - Brain, 2022 - academic.oup.com
FZR1, which encodes the Cdh1 subunit of the anaphase-promoting complex, plays an
important role in neurodevelopment by regulating the cell cycle and by its multiple post …

A rare variant nonparametric linkage method for nuclear and extended pedigrees with application to late-onset alzheimer disease via WGS data

L Zhao, Z He, D Zhang, GT Wang, AE Renton… - The American Journal of …, 2019 - cell.com
To analyze family-based whole-genome sequence (WGS) data for complex traits, we
developed a rare variant (RV) non-parametric linkage (NPL) analysis method, which has …

Currently recognized genes for schizophrenia: high‐resolution chromosome ideogram representation

MG Butler, AB McGuire, H Masoud… - American Journal of …, 2016 - Wiley Online Library
A large body of genetic data from schizophrenia‐related research has identified an
assortment of genes and disturbed pathways supporting involvement of complex genetic …

Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?

WJAJ Hendriks, RTP van Cruchten… - Frontiers in Cell and …, 2023 - frontiersin.org
Protein tyrosine phosphatases, together with protein tyrosine kinases, control many
molecular signaling steps that control life at cellular and organismal levels. Impairing …