Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-
renew by means of a controlled process of activation and proliferation of tissue-resident …

Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In
cancer, cachexia is associated with increased morbidity and mortality and decreased …

Background Cancer‐related muscle wasting occurs in most cancer patients. An important
regulator of adult muscle mass and function is the Akt–mTORC1 pathway. While Akt …

Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …