Researchers have worked for many decades to master the rules of biomolecular design that would allow artificial biopolymer complexes to self-assemble and function similarly to the …
Nanotechnology offers many benefits, and here we report an advantage of applying RNA nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …
D Jasinski, F Haque, DW Binzel, P Guo - ACS nano, 2017 - ACS Publications
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure …
D Shu, H Li, Y Shu, G Xiong, WE Carson III, F Haque… - ACS …, 2015 - ACS Publications
MicroRNAs play important roles in regulating the gene expression and life cycle of cancer cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor …
M Panigaj, MB Johnson, W Ke, J McMillan… - Therapeutic RNA …, 2021 - taylorfrancis.com
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …
Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy. Indeed, they are promising candidates to tackle the acquired resistance of surviving cells …
Y Shu, F Pi, A Sharma, M Rajabi, F Haque… - Advanced drug delivery …, 2014 - Elsevier
Human genome sequencing revealed that only~ 1.5% of the DNA sequence coded for proteins. More and more evidence has uncovered that a substantial part of the 98.5% so …
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully …