Chitosan-based nanodelivery systems for cancer therapy: Recent advances

A Narmani, SM Jafari - Carbohydrate Polymers, 2021 - Elsevier
Nowadays, cancer is one of the most prominent issues related to human health since it
causes more than one-tenth of death cases throughout the world. On the other hand, routine …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

F Pi, DW Binzel, TJ Lee, Z Li, M Sun… - Nature …, 2018 - nature.com
Nanotechnology offers many benefits, and here we report an advantage of applying RNA
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …

Advancement of the emerging field of RNA nanotechnology

D Jasinski, F Haque, DW Binzel, P Guo - ACS nano, 2017 - ACS Publications
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …

Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment

J Conde, N Oliva, M Atilano, HS Song, N Artzi - Nature materials, 2016 - nature.com
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery
vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure …

Systemic delivery of anti-miRNA for suppression of triple negative breast cancer utilizing RNA nanotechnology

D Shu, H Li, Y Shu, G Xiong, WE Carson III, F Haque… - ACS …, 2015 - ACS Publications
MicroRNAs play important roles in regulating the gene expression and life cycle of cancer
cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor …

Aptamers as modular components of therapeutic nucleic acid nanotechnology

M Panigaj, MB Johnson, W Ke, J McMillan… - Therapeutic RNA …, 2021 - taylorfrancis.com
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

RR Castillo, M Colilla, M Vallet-Regí - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.
Indeed, they are promising candidates to tackle the acquired resistance of surviving cells …

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

Y Shu, F Pi, A Sharma, M Rajabi, F Haque… - Advanced drug delivery …, 2014 - Elsevier
Human genome sequencing revealed that only~ 1.5% of the DNA sequence coded for
proteins. More and more evidence has uncovered that a substantial part of the 98.5% so …

Multifunctional RNA nanoparticles

KA Afonin, M Viard, AY Koyfman, AN Martins… - Nano …, 2014 - ACS Publications
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds
(nanorings); however, the potential of their use for biomedical applications was never fully …