Hyperinsulinaemia in cancer

EJ Gallagher, D LeRoith - Nature Reviews Cancer, 2020 - nature.com
Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

Developmental and functional control of natural killer cells by cytokines

Y Wu, Z Tian, H Wei - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Stabilizing the interphase between Li and Argyrodite electrolyte through synergistic phosphating process for all-solid-state lithium batteries

H Su, Y Liu, Y Zhong, J Li, X Wang, X Xia, C Gu, J Tu - Nano Energy, 2022 - Elsevier
Among solid electrolytes, sulfides have been considered as one of the most promising
candidates due to their soft nature and high ionic conductivity. However, the interphase …

The impact of adipose tissue–derived miRNAs in metabolic syndrome, obesity, and cancer

GS Heyn, LH Corrêa, KG Magalhães - Frontiers in endocrinology, 2020 - frontiersin.org
Obesity is a multifactorial and complex condition that is characterized by abnormal and
excessive white adipose tissue accumulation, which can lead to the development of …

Mechanisms in endocrinology: novel genetic causes of short stature

JM Wit, W Oostdijk, M Losekoot… - European Journal of …, 2016 - academic.oup.com
The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

[HTML][HTML] Hepatocellular carcinoma: a comprehensive review of biomarkers, clinical aspects, and therapy

NM Tunissiolli, MMU Castanhole-Nunes… - Asian Pacific journal …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a cause of several deaths related to cancer worldwidely.
In early stage, curative treatments such as surgical resection, liver transplant and local …

Human milk exosomal microRNA: associations with maternal overweight/obesity and infant body composition at 1 month of life

KB Shah, SD Chernausek, LD Garman, NP Pezant… - Nutrients, 2021 - mdpi.com
Among all the body fluids, breast milk is one of the richest sources of microRNAs (miRNAs).
MiRNAs packaged within the milk exosomes are bioavailable to breastfeeding infants. The …

lncRNA NR2F1‐AS1 promotes breast cancer angiogenesis through activating IGF‐1/IGF‐1R/ERK pathway

Q Zhang, T Li, Z Wang, X Kuang… - Journal of cellular and …, 2020 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) take various effects in cancer mostly through sponging
with microRNAs (miRNAs). lncRNA NR2F1‐AS1 is found to promote tumour progression in …

MicroRNAs as regulators of insulin signaling: research updates and potential therapeutic perspectives in type 2 diabetes

L Nigi, GE Grieco, G Ventriglia, N Brusco… - International journal of …, 2018 - mdpi.com
The insulin signaling pathway is composed of a large number of molecules that positively or
negatively modulate insulin specific signal transduction following its binding to the cognate …

The insulin-like growth factor signalling pathway in cardiac development and regeneration

S Díaz del Moral, M Benaouicha… - International journal of …, 2021 - mdpi.com
Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic
development, regulating processes of cell proliferation and survival. The IGF signalling …