3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

To fully understand the regulation of gene expression, it is critical to quantitatively define
whether and how RNA-binding proteins (RBPs) discriminate between alternative binding …

Refinement is a process that involves bringing into agreement the structural model,
available prior knowledge and experimental data. To achieve this, the refinement procedure …

TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two
major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its …

Abstract The type III-E CRISPR–Cas system uses a single multidomain effector called Cas7-
11 (also named gRAMP) to cleave RNA and associate with a caspase-like protease Csx29 …

Abstract 4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with
eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing) bodies …

RNA binding proteins (RBPs) modulate cancer progression through poorly understood
mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma …

PUF proteins are characterized by globular RNA-binding domains. They also interact with
partner proteins that modulate their RNA-binding activities. Caenorhabditis elegans PUF …

Simple Summary Proteins are composed of compact domains, often of known three-
dimensional structure, and natively unstructured polypeptide regions. The abundant cold …

The canonical molecular machinery required for global mRNA translation and its control has
been well defined, with distinct sets of proteins involved in the processes of translation …