Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …

In contrast to traditional perspectives of resilience as a stable, trait-like characteristic,
resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long …

Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically
before approaching its definitive treatment, joint arthroplasty. The rapidly growing …

Dehydroepiandrosterone (DHEA) and cortisol are the most abundant hormones of the
human fetal and adult adrenals released as end products of a tightly coordinated endocrine …

Aging is a complex process with an impact on essentially all organs. Declined cellular repair
causes increased damage at genomic and proteomic levels upon aging. This can lead to …

Ashwagandha (Withania somnifera) is a herb commonly used in Ayurvedic medicine to
promote youthful vigor, enhance muscle strength and endurance, and improve overall …

It is well-known that sex hormones can directly and indirectly influence immune cell function.
Different studies support a suppressive role of androgens on different components of the …

Regulatory T cells have been implicated in the regulation and maintenance of immune
homeostasis. Whether gender and sex hormones differentially influence the expression and …

Objective Mortality in patients with primary adrenal insufficiency (PAI) is significantly
increased, with respiratory infections as a major cause of death. Moreover, patients with PAI …