Abstract Knowledge of the three-dimensional structures of proteins and other biological
macromolecules often aids understanding of how they perform complicated tasks in the cell …

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence
of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport
machine capable of long-distance processive movement along microtubules. However, it is …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Autophagy is an enigmatic cellular process in which double-membrane compartments,
called “autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and …

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

ABSTRACT Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that
drives the movement of diverse cargos along the microtubule cytoskeleton, including …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …