The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The ability to take up substances from the surrounding environment not only provides cells
with vital nutrients, but also enables the selective transport of substances from one …

The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk
protein precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …

The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal
proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a …