Low-cost whole-genome assembly has enabled the collection of haplotype-resolved
pangenomes for numerous organisms. In turn, this technological change is encouraging the …

Computational pangenomics is an emerging research field that is changing the way
computer scientists are facing challenges in biological sequence analysis. In past decades …

Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

Motivation Pangenome graphs provide a complete representation of the mutual alignment of
collections of genomes. These models offer the opportunity to study the entire genomic …

Abstract We introduce STrain Resolution ON assembly Graphs (STRONG), which identifies
strains de novo, from multiple metagenome samples. STRONG performs coassembly, and …

Currently, the standard practice for assembling next-generation sequencing (NGS) reads of
viral genomes is to summarize thousands of individual short reads into a single consensus …

Error correction is the canonical first step in long-read sequencing data analysis. Current self-
correction methods, however, are affected by consensus sequence induced biases that …

Rapidly evolving RNA viruses continuously produce minority haplotypes that can become
dominant if they are drug-resistant or can better evade the immune system. Therefore, early …

Strain-Aware Assembly of Genomes from Mixed Samples Using Flow Variation Graphs |
SpringerLink Skip to main content Advertisement SpringerLink Account Menu Find a journal …

Flow network decomposition is a natural model for problems where we are given a flow
network arising from superimposing a set of weighted paths and would like to recover the …