Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

MicroRNA (miRNA) functions in the pathogenesis of major neurodegenerative diseases
such as Alzheimer's disease (AD) are only beginning to emerge. We have observed …

Alzheimer's disease (AD) is a devastating neurodegenerative disease, the most common
among the dementing illnesses. The neuropathological hallmarks of AD include …

Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …

Alzheimer's disease (AD) is a mostly sporadic brain disorder characterized by cognitive
decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex …

Abstract Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is
involved in the multiple signaling processes of a cell. Increasing evidence suggests that …

Currently, there is no effective treatment for neurodegenerative disorders such as
Alzheimer's disease and Parkinson's disease. Thus, a major focus of neuroscience research …

The overall aim of this article is to review current therapeutic strategies for treating AD, with a
focus on mitochondrially targeted antioxidant treatments. Recent advances in molecular …