Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations

KR McSweeney, LK Gadanec, T Qaradakhi, BA Ali… - Cancers, 2021 - mdpi.com
Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies

M Cascella, G Palma, A Barbieri, S Bimonte… - Nutrients, 2017 - mdpi.com
Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore,
new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is …

[HTML][HTML] Efficacy of co-administration of garlic extract and metformin for prevention of gentamicin–renal toxicity in wistar rats: A biochemical study

M Rafieian-Kopaei, A Baradaran… - … journal of preventive …, 2013 - ncbi.nlm.nih.gov
Background: Gentamicin (GM) nephrotoxicity has been related to oxidative stress. Garlic and
metformin (MF) have anti-oxadant activity and therefore, this study was aimed to evaluate …

Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation

MH Solanki, PK Chatterjee, M Gupta… - American Journal …, 2014 - journals.physiology.org
Despite its success as a potent antineoplastic agent,∼ 25% of patients receiving cisplatin
experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium …

[HTML][HTML] Cisplatin-induced nephrotoxicity; protective supplements and gender differences

M Nematbakhsh, Z Pezeshki, FE Jazi… - Asian Pacific journal …, 2017 - ncbi.nlm.nih.gov
Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The
most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the …

Magnesium attenuates cisplatin-induced nephrotoxicity by regulating the expression of renal transporters

Y Saito, K Okamoto, M Kobayashi, K Narumi… - European Journal of …, 2017 - Elsevier
Abstract Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities
caused by this potent antitumor agent. It has been reported that Mg premedication …

Nephrotoxicity of hydroalcoholic extract ofTeucrium polium in Wistar rats

Abstract Background and Objectives: Teucrium polium L.(Calpoureh) is a wild-growing
flowering plant, found abundantly in South-West of Asia, Europe and North Africa …

Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation

F Erman, M Tuzcu, C Orhan, N Sahin… - Biological trace element …, 2014 - Springer
In the present study, we investigated the effects of lycopene on the expression of organic
anion transporters (OATs), organic cation transporters (OCTs), and multidrug resistance …

Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism

AM Abbas, HF Sakr - Canadian Journal of Physiology and …, 2016 - cdnsciencepub.com
Inflammation is a major risk factor for cardiovascular complications. Magnesium sulfate
(MgSO4) has anti-inflammatory actions. Therefore we investigated the effects of …

[PDF][PDF] The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo …

M Nematbakhsh, H Nasri - Journal of research in medical …, 2013 - pdfs.semanticscholar.org
The effects of vitamin E and selenium on cisplatin‑induced nephrotoxicity in cancer patients
treated with cisplatin‑based ch Page 1 Journal of Research in Medical Sciences | July 2013 …