Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK-rearranged Myxoid Spindle Cell Neoplasm: A Clinicopathologic Series of 35 Cases Including …

MS DeSimone, I Odintsov, HK Tsai… - The American Journal …, 2024 - journals.lww.com
Anaplastic lymphoma kinase (ALK) rearrangements drive most examples of epithelioid
fibrous histiocytoma (EFH) and have been reported in an emerging family of receptor …

ALK-rearranged Mesenchymal Neoplasms With Prominent Foamy/Pseudolipogenic Cell Morphology: Expanding the Phenotypic Spectrum of: ALK: Fusion Neoplasms …

A Agaimy, R Stoehr, C Fisher… - The American Journal …, 2024 - journals.lww.com
The category of ALK-rearranged mesenchymal neoplasms has been evolving rapidly, with
reports of morphologically diverse lesions of cutaneous, soft tissue, and visceral origin …

Chapter 13: What is new in fibroblastic/myofibroblastic tumors in children

A Al-Ibraheemi, Y Zhou, E Rullo, R Alaggio - Virchows Archiv, 2024 - Springer
Fibroblastic and myofibroblastic neoplasms represent about 12% of pediatric soft tissue
tumors. Most of these neoplasms in children are either benign or locally aggressive with rare …

CD30 expression in an emerging group of mesenchymal spindle cell neoplasms with ALK fusion detected by flow cytometry and immunohistochemistry

A Iwakoshi, H Kikui, R Nakashima… - Genes …, 2024 - Wiley Online Library
An emerging group of spindle cell neoplasms harboring fusions involving NTRK or non‐
NTRK kinase genes often share characteristic S100 and/or CD34 expression; however, the …

Superficial ALK-rearranged myxoid spindle cell neoplasms: Clinicopathologic and molecular analysis of two cases and a review of the literature

W Luo, J Zheng, M Hei, Y Jiang, B Su - Annals of Diagnostic Pathology, 2024 - Elsevier
Superficial anaplastic lymphoma kinase (ALK)-rearranged myxoid spindle cell neoplasms
are a recently identified subtype of cutaneous soft tissue tumors, distinct for their co …

ALK‐rearranged, CD34‐positive spindle cell neoplasms resembling dermatofibrosarcoma protuberans: a study of seven cases

S Agrawal, B Ameline, AL Folpe, E Azzato… - …, 2024 - Wiley Online Library
Aims The majority of dermatofibrosarcoma protuberans (DFSP) harbour PDGFB or PDGFD
rearrangements. We encountered ALK expression/rearrangement in a PDGFB/D‐negative …

Pearls and Updates on Pediatric Tyrosine Kinase-Altered Tumors

CK Gestrich, A Al-Ibraheemi - Surgical Pathology Clinics, 2024 - surgpath.theclinics.com
Receptor tyrosine kinases (RTKs) are crucial cell surface receptors that activate intracellular
signaling pathways in response to external stimuli, regulating cell proliferation and survival …

ALK-rearranged mesenchymal neoplasms: a clinicopathological and molecular study of eight additional cases of an emerging group of tyrosine kinase fusion …

M Zhao, J Song, X Yin, J Xu, X Teng… - Journal of Clinical …, 2024 - jcp.bmj.com
Aims Mesenchymal neoplasms characterised by ALK fusions mainly include inflammatory
myofibroblastic tumour (IMT) and epithelioid fibrous histiocytoma (EFH). Most recently, ALK …

EMA-Positive Superficial ALK–Rearranged Myxoid Spindle Cell Neoplasm Masquerading as Perineurioma/Hybrid Nerve Sheath Tumor

S Hegazy, R Naous - The American Journal of Dermatopathology, 2024 - journals.lww.com
Superficial anaplastic lymphoma kinase (ALK)–rearranged myxoid spindle cell neoplasm
(SAMS) is a recently described entity which coexpresses ALK, CD34, and commonly S100 …

An ALK Immunohistochemical Pitfall: ALK-Positive Histiocytosis Versus Angiomatoid Fibrous Histiocytoma

J Chang, AC Greenwood, C Kidd… - … Journal of Surgical …, 2025 - journals.sagepub.com
The proliferation of recognized neoplasms related to related to rearrangements involving
kinase genes, arising in diverse somatic tissue lineages, poses an increasing challenge in …