Computational methods for modeling aptamers and designing riboswitches

S Gong, Y Wang, Z Wang, W Zhang - International journal of molecular …, 2017 - mdpi.com
Riboswitches, which are located within certain noncoding RNA region perform functions as
genetic “switches”, regulating when and where genes are expressed in response to certain …

CompaRNA: a server for continuous benchmarking of automated methods for RNA secondary structure prediction

T Puton, LP Kozlowski, KM Rother… - Nucleic acids …, 2013 - academic.oup.com
We present a continuous benchmarking approach for the assessment of RNA secondary
structure prediction methods implemented in the CompaRNA web server. As of 3 October …

Tools and techniques for the discovery of therapeutic aptamers: recent advances

L Ai, X Jiang, K Zhang, C Cui, B Liu… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The pursuit of novel therapeutic agents for serious diseases such as cancer has
been a global endeavor. Aptamers characteristic of high affinity, programmability, low …

The four ingredients of single-sequence RNA secondary structure prediction. A unifying perspective

E Rivas - RNA biology, 2013 - Taylor & Francis
Any method for RNA secondary structure prediction is determined by four ingredients. The
architecture is the choice of features implemented by the model (such as stacked basepairs …

Foldalign 2.5: multithreaded implementation for pairwise structural RNA alignment

D Sundfeld, JH Havgaard, ACMA de Melo… - …, 2016 - academic.oup.com
Abstract Motivation: Structured RNAs can be hard to search for as they often are not well
conserved in their primary structure and are local in their genomic or transcriptomic context …

PPfold 3.0: fast RNA secondary structure prediction using phylogeny and auxiliary data

Z Sükösd, B Knudsen, J Kjems, CNS Pedersen - Bioinformatics, 2012 - academic.oup.com
PPfold is a multi-threaded implementation of the Pfold algorithm for RNA secondary
structure prediction. Here we present a new version of PPfold, which extends the …

Knotify: An efficient parallel platform for RNA pseudoknot prediction using syntactic pattern recognition

C Andrikos, E Makris, A Kolaitis, G Rassias… - Methods and …, 2022 - mdpi.com
Obtaining valuable clues for noncoding RNA (ribonucleic acid) subsequences remains a
significant challenge, acknowledging that most of the human genome transcribes into …

Knotify+: toward the prediction of RNA H-type pseudoknots, including bulges and internal loops

E Makris, A Kolaitis, C Andrikos, V Moulos, P Tsanakas… - Biomolecules, 2023 - mdpi.com
The accurate “base pairing” in RNA molecules, which leads to the prediction of RNA
secondary structures, is crucial in order to explain unknown biological operations. Recently …

Full-length RNA structure prediction of the HIV-1 genome reveals a conserved core domain

Z Sükösd, ES Andersen, SE Seemann… - Nucleic acids …, 2015 - academic.oup.com
A distance constrained secondary structural model of the≈ 10 kb RNA genome of the HIV-1
has been predicted but higher-order structures, involving long distance interactions, are …

Syntactic Pattern Recognition for the Prediction of L-Type Pseudoknots in RNA

C Koroulis, E Makris, A Kolaitis, P Tsanakas… - Applied Sciences, 2023 - mdpi.com
The observation and analysis of RNA molecules have proved crucial for the understanding
of various processes in nature. Scientists have mined knowledge and drawn conclusions …