Rel/NF-κB transcription factors are key regulators of immune, inflammatory and acute phase
responses and are also implicated in the control of cell proliferation and apoptosis …

Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both
microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the …

Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-κB/IκB) complex leading to its
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …

Breast cancers often progress from a hormone-dependent, nonmetastatic, antiestrogen-
sensitive phenotype to a hormone-independent, antiestrogen-and chemotherapy-resistant …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

Chronic intestinal inflammation induced by 2, 4, 6,–trinitrobenzene sulfonic acid (TNBS) is
characterized by a transmural granulomatous colitis that mimics some characteristics of …

This invention relates to compounds based on the 3-deazapurines ring system and to
methods for making such compounds. The invention also generally relates to the field of" …

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …

Since the NF-κB/relA transcription factor is constitutively activated in human prostate cancer
cells, we determined whether blocking NF-κB/relA activity in human prostate cancer cells …

The pathogenesis and etiology of Hodgkin's disease, a common human malignant
lymphoma, is still unresolved. As a unique characteristic, we have identified constitutive …