During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Disproportionation and comproportionation reactions have become increasingly important
electron transfer events in organometallic chemistry and catalysis. The renewed interest in …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Chiral amines are commonly used in the pharmaceutical and agrochemical industries. The
strong demand for unnatural chiral amines has driven the development of catalytic …

Herein, an unprecedented synthetic route to sulfilimines via a copper-catalyzed Chan–Lam-
type coupling of sulfenamides is presented. A key to success in this novel transformation is …

Aliphatic primary amines are prevalent in natural products, pharmaceuticals, and functional
materials. While a plethora of processes are reported for their synthesis, methods that …

Over the past decade, numerous reports have focused on the development and applications
of Cu-mediated C–H functionalization reactions; however, to date, little is known about the …

The asymmetric addition of an N–H bond to various alkenes via a direct catalytic method is a
powerful way of synthesizing value-added chiral amines. Therefore, the enantio-and …

Reported herein is a modular, NiH-catalyzed system capable of proximal-selective
hydroamination of unactivated alkenes with diverse amine sources. The key to the …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …