Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …

Abstract GATA binding protein 3 (GATA3) belongs to a family of transcription factors
comprising six members. These proteins identify GATA containing sequences in the target …

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and
tissue repair. However, molecular pathways that govern their differentiation have remained …

Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in
many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver …

Background Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and
lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 …

T follicular helper (TFH) CD4 cells are crucial providers of B cell help during adaptive
immune responses. A circulating population of CD4 T cells, termed cTFH, have similarity to …

High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer.
Emerging evidence suggests that tumor-associated macrophages (TAMs) play an …

A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to
inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes …

Introduction: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3
immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also …