Dissecting lipid metabolism alterations in SARS-CoV-2

I Casari, M Manfredi, P Metharom, M Falasca - Progress in lipid research, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic that has infected over a hundred million people globally. There have been …

Virus impact on lipids and membranes

E Ketter, G Randall - Annual review of virology, 2019 - annualreviews.org
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This
includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes …

Compartmentalized replication organelle of flavivirus at the ER and the factors involved

Y Ci, L Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Flaviviruses are positive-sense single-stranded RNA viruses that pose a considerable threat
to human health. Flaviviruses replicate in compartmentalized replication organelles derived …

Glycerophospholipid remodeling is critical for orthoflavivirus infection

J Hehner, L Schneider, A Woitalla, B Ott… - Nature …, 2024 - nature.com
Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun
lipidomics of cells infected with neurotropic Zika, West Nile, and tick-borne encephalitis …

Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)

RJ Richardson, JK Fink, P Glynn, RB Hufnagel… - Advances in …, 2020 - Elsevier
Systemic inhibition of neuropathy target esterase (NTE) with certain organophosphorus (OP)
compounds produces OP compound-induced delayed neurotoxicity (OPIDN), a distal …

Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism

J Zhou, M Zhang, Q Wang, M Li, J Bai, Q Dai… - Journal of …, 2024 - journals.asm.org
Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima,
creating a specialized lipid environment conducive to viral replication, assembly, and …

Metabolomic insights into human arboviral infections: Dengue, chikungunya, and zika viruses

NM Byers, AC Fleshman, R Perera, CR Molins - Viruses, 2019 - mdpi.com
The global burden of arboviral diseases and the limited success in controlling them calls for
innovative methods to understand arbovirus infections. Metabolomics has been applied to …

Lipid metabolism as a source of druggable targets for antiviral discovery against zika and other flaviviruses

MA Martín-Acebes, N Jiménez de Oya, JC Saiz - Pharmaceuticals, 2019 - mdpi.com
The Zika virus (ZIKV) is a mosquito-borne flavivirus that can lead to birth defects
(microcephaly), ocular lesions and neurological disorders (Guillain-Barré syndrome). There …

Shaping the flavivirus replication complex: It is curvaceous!

TE Aktepe, JM Mackenzie - Cellular microbiology, 2018 - Wiley Online Library
Flavivirus replication is intimately involved with remodelled membrane organelles that are
compartmentalised for different functions during their life cycle. Recent advances in lipid …

Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti

G Manokaran, HA Flores, CT Dickson… - Proceedings of the …, 2020 - National Acad Sciences
Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in
Wolbachia-mediated virus blocking remains to be elucidated. Here, we use liquid …