Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Pluripotent stem cells are increasingly used to model different aspects of embryogenesis
and organ formation. Despite recent advances in in vitro induction of major mesodermal …

Mutations in Notch signaling pathway members cause developmental phenotypes that affect
the liver, skeleton, heart, eye, face, kidney, and vasculature. Notch associated disorders …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Introduction 3. Stem cells and mesenchymal stem cells 4. Mesenchymal stem cell lineages
4.1. Myogenic lineage 4.2. Adipogenic lineage 4.3. Chondrogenic lineage 4.4. Osteogenic …

During bone homeostasis, osteoblast and osteoclast differentiation is coupled and regulated
by multiple signaling pathways and their downstream transcription factors. Here, we show …

Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal
abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Our intention here is to provide an overview of the involvement of Notch …