The introduction of AlphaFold 21 has spurred a revolution in modelling the structure of
proteins and their interactions, enabling a huge range of applications in protein modelling …

Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

Palmitic acid (PA) is a saturated fatty acid commonly found in coconut oil and palm oil. It
serves as an energy source for the body and plays a role in the structure and function of cell …

Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane
properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso …

The fusion of mononucleated myoblasts produces multinucleated muscle fibers leading to
the formation of skeletal muscle. Myomaker, a skeletal muscle-specific membrane protein, is …

The membrane-bound O-acyltransferase (MBOAT) superfamily catalyses the transfer of acyl
chains to substrates implicated in essential cellular functions. Aberrant function of MBOATs …

Lysosomal transmembrane acetylation of heparan sulfates (HS) is catalyzed by HS acetyl-
CoA: α-glucosaminide N-acetyltransferase (HGSNAT), whose dysfunction leads to …

Metabolism is crucial for development through supporting cell growth, energy production,
establishing cell identity, developmental signaling and pattern formation. In many model …

Wnt/β-catenin signaling pathway is a classical and crucial oncogenic pathway in many
carcinomas, and Porcupine (PORCN) is an O-acyltransferase, which is indispensable and …

Acylation modifications play a central role in biological and physiological processes. Across
a range of biomolecules from phospholipids to triglycerides to proteins, introduction of a …