Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular
disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular …

Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Bee pollen is a hive product made up of flower pollen grains, nectar, and bee salivary
secretions that beekeepers can collect without damaging the hive. Bee pollen, also called …

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

UV radiation and H2O2 are the primary factors that cause skin aging. Both trigger oxidative
stress and cellular aging. It has been reported that deacetylase silent information regulator 1 …

Liver injury is one of the adverse effects of methotrexate (MTX). Ferulic acid (FA) is an
antioxidant phytochemical that confers hepatoprotective efficacy; however, its effect against …

Cardiovascular complications are the leading cause of morbidity in diabetes. Oxidative
stress and inflammation are implicated in the development and progression of diabetic …

The kidneys are vulnerable to toxicity and acute kidney injury (AKI) is the main adverse
effect associated with the clinical use of the chemotherapeutic agent cisplatin (CIS) …

Background Galangin, a bioactive flavonoid with remarkable antioxidant and anti-apoptotic
actions, has demonstrated promising amelioration of experimental hepatotoxicity …