Tumor markers are substances produced by the tumors or by other cells of the body in
response to cancer or certain benign conditions. Although most of these markers are made …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

Recent advancements in cancer research have led to some major breakthroughs; however,
the impact on overall cancer-related death rate remains unacceptable, suggesting that …

The urokinase plasminogen activator system, which is a serine protease family include
urokinase-type plasminogen activator (uPA), the uPA receptor and plasminogen activator …

The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion,
migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a …

The main physiological function of plasmin is blood clot fibrinolysis and restoration of normal
blood flow. To date, however, it became apparent that in addition to thrombolysis, the …

Pancreatic cancer is a highly aggressive malignancy that features high recurrence rates and
the poorest prognosis of all solid cancers. The urokinase plasminogen activation system …

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of
wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer …

Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by
activating ubiquitous protease plasmin in many important physiological processes. The …

Plasminogen and plasmin tether to cell surfaces through ubiquitously expressed and
structurally quite dissimilar family of proteins, as well as some nonproteins, that are …