Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality
rates among cancer-related deaths in the United States. Originating from intestinal epithelial …

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

ESGE recommends that individuals with Lynch syndrome should be followed in dedicated
units that practice monitoring of compliance and endoscopic performance measures. Strong …

The genes associated with each of the inherited syndromes of colon cancer have now been
identified, and genetic testing is available for diagnosis. These syndromes include familial …

Polycyclic aromatic hydrocarbons, eg, benzo [a] pyrene (BaP), are common dietary
pollutants with potential carcinogenic activity, while polyphenols are potential …

Mutation V600E of BRAF, a kinase-encoding gene from the RAS/RAF/MAPK pathway, in
colorectal carcinoma (CRC) suggests a sporadic origin of the disease, providing an …

Women who carry a BRCA1 or BRCA2 mutation are at high risk of breast and ovarian
cancer, and may be at moderately increased risk of other cancer types. This review …

Pinpointing heritability factors is fundamental for the prevention and early detection of
cancer. Up to one-quarter of colorectal cancers (CRCs) occur in the context of familial …

Colorectal cancer (CRC) is the fourth most common cancer among men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …