Metastasis frequently develops from disseminated cancer cells that remain dormant after the
apparently successful treatment of a primary tumour. These cells fluctuate between an …

Base editing can be applied to characterize single nucleotide variants of unknown function,
yet defining effective combinations of single guide RNAs (sgRNAs) and base editors …

The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging
SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 …

Acute myeloid leukemia (AML) is the most aggressive adult leukemia, characterized by
clonal differentiation arrest of progenitor or precursor hematopoietic cells. Intense preclinical …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

Acute leukemia is characterized by clonal heterogeneity that contributes to poor drug
responses in patients. Despite treatment advances, the occurrence of relapse remains a …

Mutations in genes encoding components of chromatin modifying and remodeling
complexes are among the most frequently observed somatic events in human cancers. For …

Epigenetic status–altering mutations in chromatin-modifying enzymes are a feature of
human diseases, including many cancers. However, the functional outcomes and cellular …

PURPOSE Revumenib, an oral, small molecule inhibitor of the menin-lysine
methyltransferase 2A (KMT2A) interaction, showed promising efficacy and safety in a phase …

Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the
oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia …