Transgenic non-human vertebrate for the in vivo production of dual specificity immunoglobulins or hypermutated heavy chain only immunoglobulins

V Germaschewski, EC Lee, H Ali, J Clube - US Patent 10,667,501, 2020 - Google Patents
C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for
animal cells for producing genetically modified animals, eg transgenic expressing …

Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies

J Clube - US Patent 10,251,377, 2019 - Google Patents
The present invention relates to humanisation of antibodies in vivo. The invention provides
non-human vertebrates, cells, populations and methods useful for humanising chi maeric …

Animal models and therapeutic molecules

EC Lee, J Clube, A Bradley - US Patent 10,149,462, 2018 - Google Patents
The invention discloses methods for the generation of chimaeric human—non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …

Antibodies, variable domains and chains tailored for human use

A Bradley, G Friedrich, EC Lee, M Strivens… - US Patent …, 2020 - Google Patents
The invention relates to the provision of antibody therapeutics and prophylactics that are
tailored specifically for human use. The present invention provides libraries, vertebrates and …

Animal models and therapeutic molecules

A Bradley, EC Lee, Q Liang, W Wang… - US Patent …, 2018 - Google Patents
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …

Animal models and therapeutic molecules

A Bradley, EC Lee, Q Liang, W Wang - US Patent 10,165,763, 2019 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
46318717&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Animal models and therapeutic molecules

A Bradley, EC Lee, Q Liang, W Wang… - US Patent …, 2019 - Google Patents
2017-09-19 Assigned to KYMAB LIMITED reassignment KYMAB LIMITED ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WANG, WEI …

Animal models and therapeutic molecules

A Bradley, EC Lee, Q Liang, W Wang… - US Patent …, 2023 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46318717&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics

G Friedrich, EC Lee, J Clube, N England - US Patent 11,051,497, 2021 - Google Patents
The invention provides improved non-human vertebrates and non-vertebrate cells capable
of expressing antibodies comprising human variable region sequences. The present …

Animal models and therapeutic molecules

A Bradley, EC Lee, Q Liang, W Wang… - US Patent …, 2023 - Google Patents
2013-10-22 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 43428834&utm_source= google_patent&utm_medium …