Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

Polycystin-1 (PC-1) is a transmembrane protein, encoded by the PKD1 gene, mutated in
autosomal dominant polycystic kidney disease (ADPKD). This common genetic disorder …

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic
nephropathy, is characterized by phenotypic variability that exceeds genic effects …

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000
individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function …

miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-
transcriptional gene expression through mRNA degradation or translational inhibition …

Background Recently, the importance of attribute-based medicine has been emphasized.
The effects of early-onset intracranial aneurysms on patients can be significant and long …

Polycystic Kidney Disease (PKD) refers to a group of disorders, driven by the formation of
cysts in renal tubular cells and is currently one of the leading causes of end-stage renal …

Autosomal dominant polycystic kidney disease is the most common monogenic disease that
causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that …

Autosomal recessive polycystic kidney disease (ARPKD) is mainly caused by variants in the
PKHD1 gene, encoding fibrocystin (FC), a large transmembrane protein of incompletely …

20 Loss of PKHD1-gene function causes autosomal recessive polycystic kidney disease 21
(ARPKD) characterized by bilateral severely enlarged kidneys and congenital liver fibrosis …