Activation mechanisms of the VPS34 complexes

Y Ohashi - Cells, 2021 - mdpi.com
Phosphatidylinositol-3-phosphate (PtdIns (3) P) is essential for cell survival, and its
intracellular synthesis is spatially and temporally regulated. It has major roles in two …

Biology of endophilin and it's role in disease

LQ Yang, AF Huang, WD Xu - Frontiers in Immunology, 2023 - frontiersin.org
Endophilin is an evolutionarily conserved family of protein that involves in a range of
intracellular membrane dynamics. This family consists of five isoforms, which are distributed …

Structural insights into membrane remodeling by SNX1

Y Zhang, X Pang, J Li, J Xu… - Proceedings of the …, 2021 - National Acad Sciences
The sorting nexin (SNX) family of proteins deform the membrane to generate transport
carriers in endosomal pathways. Here, we elucidate how a prototypic member, SNX1, acts in …

Occurrence and evolutionary conservation analysis of α‐helical cationic amphiphilic segments in the human proteome

ISD Costa, T Junot, FL Silva, W Felix… - The FEBS …, 2024 - Wiley Online Library
The existence of encrypted fragments with antimicrobial activity in human proteins has been
thoroughly demonstrated in the literature. Recently, algorithms for the large‐scale …

Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii

N Al-Qatabi, M Magdeleine, S Pagnotta, A Leforestier… - bioRxiv, 2024 - biorxiv.org
Toxoplasma gondii, the causative agent of toxoplasmosis, infects cells and replicates inside
via the secretion of factors stored in specialized organelles (rhoptries, micronemes, dense …

Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers

A Thorlacius, M Rulev, O Sundberg, A Sundborger - bioRxiv, 2024 - biorxiv.org
Bin/Amphiphysin/Rvs (BAR) domain containing proteins are cytosolic, peripheral membrane
proteins that regulate the curvature of membranes in eukaryotic cells. BAR protein …

Characterization of Dnajc12 knock-out mice, a model of hypodopaminergia

IB Deng, J Follett, JD Fox, S Wall, MJ Farrer - bioRxiv, 2024 - biorxiv.org
Abstract Homozygous DNAJC12 c. 79-2A> G (p. V27Wfs* 14) loss-of-function mutations
were first reported as a cause of young-onset Parkinson's disease. However, bi-allelic …

GTP hydrolysis triggers membrane remodeling by AMPH-1

W Gai, Y Wang, J Zhang, C Carr, H Rye - bioRxiv, 2024 - biorxiv.org
Membrane-enclosed transport carriers return biological molecules from the recycling
endosome to the plasma membrane using a mechanism that is not well understood. In C …

Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers

A Sundborger-Lunna, A Thorlacius, M Rulev… - 2024 - researchsquare.com
Abstract Bin/Amphiphysin/Rvs (BAR) domain containing proteins are cytosolic, peripheral
membrane proteins that regulate the curvature of membranes in eukaryotic cells. BAR …

Mechanism of Membrane Fission by Yeast Amphiphysin

X Gong - 2022 - oaktrust.library.tamu.edu
Solutes and nutrients are internalized by endocytosis and delivered to early endosomes in
membranous transport carriers in eukaryotic cells. The release of these carriers into the cell …