Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-
1,-2, and-3 promote cell proliferation and survival downstream of cytokine and growth factor …

The initiation and progression of human cancer is frequently linked to the uncontrolled
activation of survival kinases. Two such pro-survival kinases that are commonly amplified in …

The human pim-1 gene encodes a serine/threonine kinase, which belongs to the group of
calcium/calmodulin-regulated kinases (CAMK). It contains a characteristic kinase domain, a …

The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of
serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that …

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed
cell death by phosphorylating substrates that regulate both apoptosis and cellular …

The serine/threonine kinase Pim is known to promote cell cycle progression and to inhibit
apoptosis leading to tumorigenesis. However, the precise mechanisms remain unclear. We …