Hippocampal neurophysiologic changes after mild traumatic brain injury and potential neuromodulation treatment approaches

F Girgis, J Pace, J Sweet, JP Miller - Frontiers in systems …, 2016 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause of death and disability in individuals below
age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI) …

The roles of neurotrophins in traumatic brain injury

PH Lin, LT Kuo, HT Luh - Life, 2021 - mdpi.com
Neurotrophins are a collection of structurally and functionally related proteins. They play
important roles in many aspects of neural development, survival, and plasticity. Traumatic …

Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats

PK Dash, SA Orsi, M Zhang, RJ Grill, S Pati, J Zhao… - PloS one, 2010 - journals.plos.org
Background Traumatic brain injury (TBI) initiates a complex series of neurochemical and
signaling changes that lead to pathological events including neuronal hyperactivity …

Sulforaphane improves cognitive function administered following traumatic brain injury

PK Dash, J Zhao, SA Orsi, M Zhang, AN Moore - Neuroscience letters, 2009 - Elsevier
Recent studies have shown that sulforaphane, a naturally occurring compound that is found
in cruciferous vegetables, offers cellular protection in several models of brain injury. When …

Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury

PK Dash, SA Orsi, AN Moore - Neuroscience, 2009 - Elsevier
Traumatic brain injury (TBI) induces a number of pathological events ranging from neuronal
degeneration and tissue loss to impaired neuronal plasticity and neurochemical …

Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome

PK Dash, D Johnson, J Clark, SA Orsi, M Zhang… - PloS one, 2011 - journals.plos.org
Background Traumatic brain injury (TBI) sets in motion cascades of biochemical changes
that result in delayed cell death and altered neuronal architecture. Studies have …

Microenvironment changes in mild traumatic brain injury

EM Kan, EA Ling, J Lu - Brain research bulletin, 2012 - Elsevier
Traumatic brain injury (TBI) is a major public-health problem for which mild TBI (MTBI)
makes up majority of the cases. MTBI is a poorly-understood health problem and can persist …

Expression profile of plasma microRNAs and their roles in diagnosis of mild to severe traumatic brain injury

X Qin, L Li, Q Lv, Q Shu, Y Zhang, Y Wang - PloS one, 2018 - journals.plos.org
Traumatic brain injury (TBI) is associated with trauma-related death. In this study, we
evaluated differences in the expression of plasma microRNAs (miRNAs) in patients with …

Neurodegeneration in the somatosensory cortex after experimental diffuse brain injury

J Lifshitz, AM Lisembee - Brain Structure and Function, 2012 - Springer
Disruption and consequent reorganization of central nervous system circuits following
traumatic brain injury may manifest as functional deficits and behavioral morbidities. We …

Na+, K+-ATPase activity impairment after experimental traumatic brain injury: relationship to spatial learning deficits and oxidative stress

FD Lima, MA Souza, AF Furian, LM Rambo… - Behavioural Brain …, 2008 - Elsevier
Traumatic brain injury (TBI) is a devastating disease that commonly causes persistent
mental disturbances and cognitive deficits. Although studies indicate that oxidative stress …