Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

The majority of the human genome encodes RNAs that do not code for proteins. These non-
coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …

Background Standard treatments against bacterial infections are becoming ineffective due to
the rise of antibacterial resistance worldwide. Classical approaches to develop new …

Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes
infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to …

With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and
molecular transporters have started to be investigated as alternative antibacterials or anti …

Bacterial infections caused by intracellular pathogens are difficult to control. Conventional
antibiotic therapies are often ineffective, as high doses are needed to increase the number …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Highlights•A LNA–DNA hybrid oligomer (miravirsen) is targeted to a host micro RNA instead
of the pathogen (hepatitis C virus)•Miravirsen demonstrates broad antiviral activity against …