SARS-CoV-2 biology and host interactions

S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

The development of proximity labeling technology and its applications in mammals, plants, and microorganisms

J Guo, S Guo, S Lu, J Gong, L Wang, L Ding… - Cell Communication and …, 2023 - Springer
Abstract Protein‒protein, protein‒RNA, and protein‒DNA interaction networks form the
basis of cellular regulation and signal transduction, making it crucial to explore these …

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

O Danziger, RS Patel, EJ DeGrace, MR Rosen… - PLoS …, 2022 - journals.plos.org
Interferons establish an antiviral state through the induction of hundreds of interferon-
stimulated genes (ISGs). The mechanisms and viral specificities for most ISGs remain …

[HTML][HTML] Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins

YB Lee, M Jung, J Kim, A Charles, W Christ, J Kang… - Cell reports, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells
by interacting with host factors following infection. To understand the virus and host …

Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics

SY Luo, EW Moussa, J Lopez-Orozco… - ACS Infectious …, 2023 - ACS Publications
The recent emergence of SARS-CoV-2 in the human population has caused a global
pandemic. The virus encodes two proteases, Mpro and PLpro, that are thought to play key …

Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection

J Quan, Q Fan, LM Simons, SN Smukowski, C Pegg… - MBio, 2024 - journals.asm.org
Neurotropic alphaherpesviruses, including herpes simplex virus type 1 and pseudorabies
virus, establish a lifelong presence within the peripheral nervous system of their mammalian …

High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface

S Datta, DY Chen, AH Tavares, T Reyes-Robles… - Cell Chemical …, 2023 - cell.com
Identifying virus-host interactions on the cell surface can improve our understanding of viral
entry and pathogenesis. SARS-CoV-2, the causative agent of the COVID-19 disease, uses …

Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis

E Partiot, A Hirschler, S Colomb, W Lutz, T Claeys… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with
short-and long-term neurological complications. The variety of symptoms makes it difficult to …

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

GJ Pearson, HV Mears, M Broncel, AP Snijders… - Science …, 2024 - science.org
The β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
causative agent of the global COVID-19 pandemic. Coronaviral Envelope (E) proteins are …

[HTML][HTML] Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

L Delhaye, GD Moschonas, D Fijalkowska… - Cell Reports …, 2024 - cell.com
Protein-protein interactions play an important biological role in every aspect of cellular
homeostasis and functioning. Proximity labeling mass spectrometry-based proteomics …