Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

The determination of molecular features that mediate clinically aggressive phenotypes in
prostate cancer remains a major biological and clinical challenge,. Recent advances in …

We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-
helical peptide to enter clinical trials. ALRN-6924 is a “stapled peptide” that mimics the N …

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …

The role of PPM1D mutations in de novo gliomagenesis has not been systematically
explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas …

Diffuse large B-cell lymphoma (DLBCL) remains a formidable diagnosis in need of new
treatment paradigms. In this work, we elucidated an opportunity for therapeutic synergy in …