Lycopene: a natural arsenal in the war against oxidative stress and cardiovascular diseases

MN Bin-Jumah, MS Nadeem, SJ Gilani, B Mubeen… - Antioxidants, 2022 - mdpi.com
Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables,
including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research …

Oxidative stress, mitochondrial damage and neurodegenerative diseases

C Guo, L Sun, X Chen, D Zhang - Neural regeneration research, 2013 - journals.lww.com
Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of
several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease …

[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning

M Eshraghi, M Ahmadi, S Afshar, S Lorzadeh… - Pharmacology & …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

[HTML][HTML] Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease

L La Barbera, F Vedele, A Nobili, P Krashia… - Progress in …, 2021 - Elsevier
What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease

GS Gaki, AG Papavassiliou - Neuromolecular medicine, 2014 - Springer
Parkinson's disease is the second most common neurodegenerative movement disorder;
however, its etiology remains elusive. Nevertheless, in vivo observations have concluded …

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

AL Mahul-Mellier, B Fauvet, A Gysbers… - Human molecular …, 2014 - academic.oup.com
Increasing evidence suggests that the c-Abl protein tyrosine kinase could play a role in the
pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. c-Abl has …

The role of c-Abl tyrosine Kinase in brain and its pathologies

H Motaln, B Rogelj - Cells, 2023 - mdpi.com
Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …

Alpha synuclein post translational modifications: potential targets for Parkinson's disease therapy?

V Brembati, G Faustini, F Longhena… - Frontiers in molecular …, 2023 - frontiersin.org
Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

c-Abl and Parkinson's disease: mechanisms and therapeutic potential

S Brahmachari, SS Karuppagounder… - Journal of …, 2017 - content.iospress.com
Although the etiology of Parkinson's disease (PD) is poorly understood, oxidative stress has
long been implicated in the pathogenesis of the disease. However, multifaceted and …

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

F Rojas, D Gonzalez, N Cortes, E Ampuero… - Frontiers in cellular …, 2015 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which
pathogenesis and death of motor neurons are triggered by non-cell-autonomous …