The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

During development, secreted morphogens such as Wnt, Hedgehog (Hh), and BMP emit
from their producing cells in a morphogenetic field, and specify different cell fates in a direct …

Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1).
However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1 …

Hedgehog (Hh) proteins are secreted signaling molecules that mediate essential tissue-
patterning events during embryonic development and function in tissue homeostasis and …

Hedgehog (Hh) proteins regulate important developmental processes, including cell
proliferation and differentiation. Although Patched acts as the main Hh receptor in …

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate
Hedgehoghomologs, and is essential for proper embryonic development. Shh binds to its …

In contrast to the functional role of heparan sulfate proteoglycans (HSPGs), the importance
of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving …

Stem cells reside in adult and embryonic tissues in a broad spectrum of developmental
stages and lineages, and they are thus naturally exposed to diverse microenvironments or …

Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration.
Dysregulation of this pathway is associated with several types of cancer. The monoclonal …