Astrocyte senescence promotes glutamate toxicity in cortical neurons

C Limbad, TR Oron, F Alimirah, AR Davalos, TE Tracy… - PloS one, 2020 - journals.plos.org
Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer's and related dementias and cancer patients after chemo-or radio …

[HTML][HTML] Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2

AQ Yu, ZX Wang, W Wu, KY Chen, SR Yan… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Abstract Circular RNAs (CircRNAs) are a novel subset of non-coding RNA widely present in
eukaryotes that play a central role in physiological and pathological conditions …

Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson's disease focusing on correlations with motor symptoms

D Pham, B Polgar, T Toth, A Jungling, N Kovacs… - Geroscience, 2022 - Springer
The neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP)
have been shown in numerous in vitro and in vivo models of Parkinson's disease (PD) …

[HTML][HTML] Microdose lithium reduces cellular senescence in human astrocytes-a potential pharmacotherapy for COVID-19?

T Viel, S Chinta, A Rane, M Chamoli, H Buck… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Cell senescence is a process that causes growth arrest and the release of a senescence
associated secretory phenotype (SASP), characterized by secretion of chemokines …

[HTML][HTML] Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice

X Bai, X Zhang, R Fang, J Wang, Y Ma, Z Liu… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
Studies reveal a linkage of miR-29s in aging and Parkinson's disease (PD). Here we show
that the serum levels of miR-29s in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

[HTML][HTML] Aging is associated with glial senescence in the brainstem-implications for age-related sympathetic overactivity

P Balasubramanian, L Branen… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Accumulating evidence suggests that the sympathetic nervous system (SNS) overactivity
plays a crucial role in age-related increase in the risk for cardiovascular diseases such as …

Deficiency of miR-29a/b1 leads to premature aging and dopaminergic neuroprotection in mice

X Bai, J Wang, X Zhang, Y Tang, Y He… - Frontiers in Molecular …, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive
degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a …

[HTML][HTML] Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet …

CH Pan, CJ Chen, CM Shih, MF Wang, JY Wang… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
The relationship between aging and restenosis are unclear. The purposes of this study were
to investigate the possible pathological role and mechanism of aging on formation of …

Reduced efficiency of DNA repair and antioxidant defense promotes the accumulation of DNA damage during cell senescence

PI Deryabin, AV Borodkina - Cell and Tissue Biology, 2021 - Springer
The accumulation of senescent cells within the organism positively correlates with age and
is considered as one of the risk factors for an age-dependent increase in the incidence of …

Senescencia celular en enfermedades neurodegenerativas

C Silvino Sánchez - 2021 - repositorio.unican.es
La senescencia celular, un proceso implicado en el mantenimiento de la integridad del
organismo ante factores perturbadores de la homeostasis celular, tiene un papel …