A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell
metabolism has been thoroughly investigated and covered in reviews. However, there is …

Neuroendocrine neoplasms (NENs) can develop in almost any organ and span a spectrum
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …

Background Metastatic high-grade neuroendocrine neoplasms (G3NENs) have limited
treatment options after progression on platinum-based therapy. We addressed the role of …

Purpose: Patients with recurrent or metastatic neuroendocrine neoplasms (NEN) had a poor
prognosis and few treatment options. Toripalimab, a humanized IgG4 antibody specific for …

Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …

Poorly differentiated neuroendocrine carcinomas (PD-NEC) are rare cancers garnering
interest as they become more commonly encountered in the clinic. This is due to improved …

Background: In gastroenteropancreatic (GEP) high-grade neuroendocrine neoplasms (H-
NENs), Ki-67 threshold of 55% defines three prognosis subclasses: neuroendocrine tumor …

Gastroenteropancreatic neuroendocrine neoplasia (GEPNEN) comprises clinically as well
as prognostically diverse tumour entities often diagnosed at late stage. Current classification …

Opinion statement Treatment recommendations for advanced gastroenteropancreatic
neuroendocrine carcinomas (GEP-NEC) are based on uncontrolled, mainly retrospective …

Gastroenteropancreatic neuroendocrine tumors (GEP‐NETs) are heterogeneous
malignancies that arise from complex cellular interactions within the tissue …