Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …

Cholestasis is the predominate feature of many pediatric hepatobiliary diseases. The
physiologic flow of bile requires multiple complex processes working in concert. Bile acid …

Background & Aims Although water channel aquaporin-8 (AQP8) has been implicated in
hepatic bile formation and liver diseases associated with abnormal bile flow in human and …

Data on cholestasis and biliary injury in patients with COVID-19 are scarce. The primary aim
of this study was to evaluate the prevalence of cholestasis and factors associated with its …

Tiny amount of bacteria are found in the pancreas in pancreatitis and cancer, which seemed
involved in inflammation and carcinogenesis. However, bacterial infiltration from the …

Cholestasis is a multifactorial hepatobiliary disorder, characterized by obstruction of bile flow
and accumulation of bile, which in turn causes damage to liver cells and other tissues. In …

Alcohol-related liver disease (ALD) impacts millions of patients worldwide each year and the
numbers are increasing. Disease stages range from steatosis via steatohepatitis and fibrosis …

Background Alcohol-related liver disease (ALD) is a major chronic liver ailment caused by
alcohol overconsumption and abuse. Apolipoprotein H (APOH) participates in lipid …

Successful histogenetic research relies on proper handling of tissue samples to maximize
DNA quality. As the largest gland in the body, the liver is particularly sensitive to sample …

Bile acids (BA) are known to influence the susceptibility of hepatocytes to chemicals. We
investigated the cytotoxicity of 18 compounds with known hepatotoxicity status and …