Analytical sample preparation strategies for the determination of antimalarial drugs in human whole blood, plasma and urine
ME Casas, M Hansen, KA Krogh, B Styrishave… - … of Chromatography B, 2014 - Elsevier
Antimalarial drugs commonly referred to as antimalarials, include a variety of compounds
with different physicochemical properties. There is a lack of information on antimalarial …
with different physicochemical properties. There is a lack of information on antimalarial …
Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium …
Malaria affects more than 200 million people annually around the world, killing a child every
2 min. Artemether (ART) and lumefantrine (LUM) are the gold standard choice to treat …
2 min. Artemether (ART) and lumefantrine (LUM) are the gold standard choice to treat …
Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether
Monitoring antimalarial drugs is necessary for clinical assays, human health, and routine
quality control practices in pharmaceutical industries. Herein, we present the development of …
quality control practices in pharmaceutical industries. Herein, we present the development of …
Five Different Artemisia L. Species Ethanol Extracts' Phytochemical Composition and Their Antimicrobial and Nematocide Activity
E Nikitin, I Fitsev, A Egorova, L Logvinenko… - International Journal of …, 2023 - mdpi.com
Among the plants that exhibit significant or established pharmacological activity, the genus
Artemisia L. deserves special attention. This genus comprises over 500 species belonging …
Artemisia L. deserves special attention. This genus comprises over 500 species belonging …
Bioanalysis of antimalarials using liquid chromatography
Among the most central aspects of the drug-development process is estimation of drug
levels in biological systems, which is an integral part of preclinical and clinical studies. Once …
levels in biological systems, which is an integral part of preclinical and clinical studies. Once …
Determination of lumefantrine in small-volume human plasma by LC–MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation
L Huang, X Li, F Marzan, PS Lizak, FT Aweeka - Bioanalysis, 2012 - Taylor & Francis
Background: To support pediatric study, a method to determine lumefantrine (LF) with small
sample volume is needed. Matrix effect (ME) is a daunting issue in LF quantification in …
sample volume is needed. Matrix effect (ME) is a daunting issue in LF quantification in …
Molecularly imprinted polymer for determination of lumefantrine in human plasma through chemometric-assisted solid-phase extraction and liquid chromatography
Lumefantrine is the first-choice treatment of Falciparum uncomplicated malaria. Recent
findings of resistance to lumefantrine has brought attention for the importance of therapeutic …
findings of resistance to lumefantrine has brought attention for the importance of therapeutic …
[PDF][PDF] Simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in tablet dosage form
R Arun, AA Smith - Int J Pharm Biomed Res, 2011 - academia.edu
This paper describes the development and validation of a simultaneous HPLC-UV method
for the estimation of artemether and lumefantrine in fixed-dose combination tablets. The …
for the estimation of artemether and lumefantrine in fixed-dose combination tablets. The …
Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software
Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is
considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its …
considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its …
Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from …
RATIONALE Artemisinin‐based drugs and their metabolites are prone to in‐source
fragmentation under atmospheric pressure ionisation mass spectrometry (API‐MS) …
fragmentation under atmospheric pressure ionisation mass spectrometry (API‐MS) …