Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

Obesity is one of the most serious global health problems, with an incidence that increases
yearly and coincides with the development of cancer. Adipose tissue macrophages (ATMs) …

Obesity hypoventilation syndrome (OHS) is defined as daytime hypercapnia in obese
individuals in the absence of other underlying causes. In the United States, OHS is present …

Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte
sensitivity to insulin to restrain lipid accrual. This adipokine may modulate the production of …

Obesity is a chronic inflammatory disease that affects more than 1 billion people worldwide
and is associated with various metabolic and physiological dysfunctions, directly impacting …

Leptin modulates insulin signaling and this involves the Akt pathway, which is influenced by
changes in the inflammatory environment and with leptin regulating cytokine synthesis. We …

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. This
chapter provides an overview of the biological pathways of CVD risk. Molecular …

Obezite, günümüzün ve geleceğimizin önemli bir halk sağlığı sorunudur. Ana patolojik
mekanizma, artan enerji girdisine fizyolojik yanıt veremeyip hipertrofi ile büyüme gösteren …

OBJECTIVE: Obesity was induced in rats by feeding on a high fat diet (HFD), 60% w/w
cholesterol, 20% w/w carbohydrates, and 20% w/w proteins for two months. MATERIALS …